دوشنبه 3 مهر 1396
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   سپتامبر 25, 2017
   
   
     
  تعداد اعضاء : 2821 نفر
  بازدیدهای امروز :738 بار
  تعداد کل بازدیدها : 938735 بار
   
Volume: 38
Year: 2016
Month: 7
Subject Others
Title Study of FokI and ApaI Polymorphisms of Vitamin D Receptor Gene in Iranian Postmenopausal Women with Osteoporosis
Authors Sharareh Salehi; Heidar Sharafi; Seyed Mojtaba Hakim; Gholam Hosein Ranjbar Omrani; Fatemeh Ebrahimi; Ali Pouryasin;
Abstract Background & Objectives: Osteoporosis along with decreased bone density can lead to bone structure loss which increases the risk of fractures. Recent identification of genetic factors impels researchers to assess association of genetic variations with osteoporosis. The aim of this study was to evaluate the relationship between FokI and ApaI polymorphisms of vitamin D receptor (VDR) gene and serum calcium level, serum 25-OH vitamin D level and osteoporosis in Iranian postmenopausal women. Materials and Methods: In this study, we included 194 over 50 years old postmenopausal women with osteoporosis and osteopenia and 50 over 50 years old healthy postmenopausal women as the control group. To study the polymorphisms, genomic DNA was extracted from blood samples containing EDTA anticoagulant. Genotyping of FokI and ApaI polymorphisms of VDR gene was performed using PCR-RFLP method. Results: Weight, height, age, serum 25-OH vitamin D, and calcium level were compared in three groups of control, osteopenia, and osteoporosis. The mean of serum calcium level was not significantly different but the means of age, weight, height, and serum 25-OH vitamin D level were significantly different between the patients and control group. Also, the differences in the distribution of FokI and ApaI genotypes were not statistically significant among the patients with osteopenia, osteoporosis and the control group. Conclusion: It seems that there is no association between FokI and ApaI polymorphisms of VDR gene and osteoporosis.
-Calcium, Genetic polymorphism, Osteoporosis, Vitamin D receptor
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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