جمعه 31 شهريور 1396
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   سپتامبر 22, 2017
   
   
     
  تعداد اعضاء : 2819 نفر
  بازدیدهای امروز :388 بار
  تعداد کل بازدیدها : 936858 بار
   
Volume: 38
Year: 2016
Month: 12
Subject Others
Title Frequency of Thrombophilic Gene Polymorphisms in Cirrhotic Patients with Splanchnic Vein Thrombosis in Comparison with Cirrhotic Patients without Thrombosis
Authors Mohammad Hossein Somi; Bita Sepehri; Morteza Bonyadi;
Abstract Background & Objectives: Visceral thrombosis especially hepatic vein thrombosis deteriorates the disease in cirrhotic patients. Thrombophilic genotypes are seen in most cirrhotic patients with portal vein thrombosis. The aim of this study is the comparison of thrombophilic genes frequency in cirrhotic patients with splanchnic veins thrombosis versus cirrhotic patients without thrombosis. Materials & Methods: In a case – control study, we studied 100 patients with hepatic cirrhosis in Tabriz Imam Reza hospital after achieving inclusion criteria in the form of two groups (with and without visceral veins thrombosis). The frequency of genetic polymorphism of thrombophilia in two groups of cirrhotic patients was assessed. Results: The mean age of the patients was 48.1±18.1 years which were in the range of 15 to 85 years. 51 (51%) of patients were male and 49 (49%) were female. Thrombosis was present in portal vein in 24% of patients, in superior mesenteric vein in 7% of patients, in splenic vein in 14% and in 5% of patients in potal and splenic veins. There was no significant difference between two groups in G20210A, C677T, A1298C and PAI-I genes polymorphism (P=0.82, P=0.70, P=0.78 respectively). Conclusion: With regard to the non-significant difference in frequency of thrombophilic gene polymorphism in two groups, we cannot assume prophylactic actions in cirrhotic patients for visceral vein thrombosis but we recommend more multicentric studies with more number of cases for clarifying the topic.
-Genetic Polymorphism, Thrombophilia, Cirrhosis
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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