جمعه 31 شهريور 1396
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   سپتامبر 22, 2017
   
   
     
  تعداد اعضاء : 2819 نفر
  بازدیدهای امروز :363 بار
  تعداد کل بازدیدها : 936833 بار
   
Volume: 39
Year: 2017
Month: 4
Subject Others
Title Decreased activity of matrix metalloproteinases in gastric cancer stem cells by treatment with ibuprofen
Authors Fatemeh Mahmoodi; Hassan Akrami;
Abstract Background: Metastasis is the main cause of cancer-related death. Matrix metalloproteinases (MMPs) play an important role in tumor migration and are known as the main factors in metastasis. Cancer stem cells are a rare population of tumor cells responsible for initiation, spreading and growth of cancer. Ibuprofen, a member of nonsteroidal anti-inflammatory drugs (NSAIDs) family is used for the prevention and treatment of certain cancers. In the present study, we investigate the effect of ibuprofen on metalloproteinase activity in gastric cancer cells. Methods: Gastric cancer stem cell of MKN45 cell lines was isolated by the spheroid colony formation technique. Gastric cancer stem cells were treated with various concentrations of ibuprofen to achieve the IC50 values. MMP activity in Gastric cancer stem cells treated with ibuprofen compared to control cells was investigated by zymography technique. Results: Metalloproteinase activity was reduced in the cancer stem cells treated with ibuprofen in comparison with the control cancer stem cells. Conclusions: Ibuprofen inhibits metastatic ability of gastric cancer cells by reducing metalloproteinase activity in gastric cancer stem cells.
Keywords: Ibuprofen, Zymography, Cancer Stem Cells, Metalloproteinase, Metastasis
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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