سه شنبه 30 آبان 1396
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   نوامبر 21, 2017
   
   
     
  تعداد اعضاء : 2866 نفر
  بازدیدهای امروز :90 بار
  تعداد کل بازدیدها : 966963 بار
   
Volume: 39
Year: 2017
Month: 7
Subject Others
Title Determine effect of weight loss on serum level of inflammatory cytokines IL-1β, IL-6, CRP andTNF-α in obese patients with fatty liver disease
Authors Mohammad Hossein Somi; Kamal Boostani; Saleh Azadbakht; Mohammad Alizadeh; Amir Taher Eftekharsadat; Morteza Ghojazadeh;
Abstract Background: Obesity results in a chronic inflammatory state leading to long term adverse effects. The aim of this study is to evaluate effect of low calorie diet and weight loss on serum level of inflammatory markers in patients with fatty liver disease in Iranian population. Methods: In a clinical trial, 40 patients with fatty liver disease in Gastro-hepathology clinic of Tabriz Imam Reza hospital were introduced to receive a low calorie diet.Serum level of proinflammatory factors (IL-1, IL-6, TNF-α and Hs-CRP) were measured and compared before and after an 8 week trial of diet. Results: The mean age of the patients was 45.36±10.51 years (range: 23-70). Nine (22.5%) patients were male and 41 (77.5%) was females. The mean value of weight and body mass index of participants decreased significantly after 8 weeks (a mean decrease of 6.47± 3.40 percent in weight). Weight loss in men was significantly more than women. The mean level of IL-1, IL-6, TNF-α and Hs-CRP was significantly decreased after weight loss in both men and women. There was no correlation between amount of weight loss withdegree of decrease ininflammatory markers. Decrease of TNF-α was significantly more in younger patients. Conclusion: Weight loss with low calorie diet can decrease the level of IL-1, IL-6, TNF-α and Hs-CRP of patients with fatty liver during 8 weeks independent from gender and degree of weight loss.
Obesity, Cytokines, weight loss, fatty liver
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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