يکشنبه 25 آذر 1397
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   ديسمبر 16, 2018
   
   
     
  تعداد اعضاء : 3193 نفر
  بازدیدهای امروز :505 بار
  تعداد کل بازدیدها : 276842 بار
   
Volume: 40
Year: 2018
Month: 2
Subject Others
Title Efficacy of uteral injection of G-CSF in repeated implantation failure: A clinical trial study
Authors Faranak Jalilvand; Aleye Gasemzadeh; Kobra Hamdi; Nazli Navali; Helen Pia; Laya Farzadi;
Abstract Background: Despite advances in clinical and laboratory techniques, including stimulating ovulation and transferring embryo, success rate of pregnancy remains is about 30%. The aim of this study was to assess the effect of intra uterine G-CSF on implantation and clinical pregnancy rate in patients with implantation failure in IVF. Methods: This study was a randomized clinical trial on patients undergoing in vitro fertilization within an age range of 45-18 years and a history of failure in implantation for two or more times. A total of 34 patients receiving G-CSF in the intervention group and 38 patients in the control group were enrolled. Results: Mean age of the participants was 34.1 years with a standard deviation of 6.4 years. The average number of years of fertility was 10 years with a standard deviation of 5.2 years. The average number of embryos implanted in the intervention group was 2.88 with a standard deviation of 0.33. The figures for the control group were 2.97 and 0.37, respectively. The two groups did not differ significantly. With respect to the potential clinical and laboratory fertility outcomes, including existing gestational sac with observed heart rate and positive serum βHCG, no statistically significant difference was observed between the two groups. Conclusion: It seems that the effect of G-CSF on improving fertility outcomes in patients with implantation failure does not exist and more related studies are recommended in this regard.
_In vitro fertilization, Infertility, G-CSF, Clinical trial
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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