يکشنبه 3 تير 1397
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   ژوئن 24, 2018
   
   
     
  تعداد اعضاء : 3027 نفر
  بازدیدهای امروز :118 بار
  تعداد کل بازدیدها : 119420 بار
   
Volume: 40
Year: 2018
Month: 2
Subject Others
Title Comparison between preventive antibiotic regimes of cefazolin with or without Azithromycin in cesarean surgical site infection
Authors Nazli Navali; Sanaz Moosavi; Maryam Baradaran Binazir; Atiyeh Amidfar;
Abstract Background: Wound infection is not uncommon after cesarean sections. Using a first-generation cephalosporin (cefazolin) has been recommended for antibiotic prophylaxis in patients, but according to few reports, extending the spectrum of antibiotic prophylaxis by adding azithromycin to the standard cephalosporin may lead to extra protection against postcesarean infections. The relevant available data are not enough to draw a solid conclusion. This study aimed to compare the effectiveness of conventional antibiotic prophylaxis using cefazolin with a combination of cefazolin and azithromycin in reducing wound infection. Methods: In this randomized clinical trial, candidates of cesarean section were categorized in two groups; cases (n=85) who received intraoperative cefazolin plus postoperative oral azithromycin (500 gr) and controls (n=86) who received intraoperative cefazolin only. The incidence rate of surgical wound infection by 30 days postoperation was compared between the two groups. Results: Cesarean sections were emergency in 80% of cases and 89.5% of controls (p=0.08). Postcesarean incisional wound infection developed in 4.7% of controls, whereas no patient in the case group had such infection (p=0.12). Conclusion: Compared to cefazolin alone, a combination of azithromycin and cefazolin was more effective in preventing postcesarean incisional wound infection, the difference was not significant. Nonetheless, owing to this advantageous clinical consequence using a combination of these two antibiotics instead of cefazolin alone is recommended.
Keywords: Prophylaxis, Azithromycin, Cesarean, Wound Infection
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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