يکشنبه 25 آذر 1397
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   ديسمبر 16, 2018
   
   
     
  تعداد اعضاء : 3193 نفر
  بازدیدهای امروز :406 بار
  تعداد کل بازدیدها : 276743 بار
   
Volume: 40
Year: 2018
Month: 9
Subject Others
Title Association study of the rs12255372 and rs290487 polymorphisms in the TCF7L2 gene with type 2 diabetes in Arab ethnic of Khuzestan province
Authors Iman Mousavi Nasab; Ali Mohammad Forough mand; Mehdi Poormehdi Brogeni; Peyman Paiami;
Abstract Background: TCF7L2 gene encodes a transcription factor that plays an important role in the Wnt signaling pathway. In this pathway TCF7L2 protein induces transcription of genes involved in glucose homeostasis, such as intestinal proglucagon. The aim of present study was to investigate the association of rs12255372, and rs290487 polymorphisms of TCF7L2 with T2DM in Arab ethnic of Khuzestan province in Iran. Methods: 100 patients with T2D and 97 normoglycemic subjects were included in this study. The PCR-RFLP and TETRA ARMS- PCR technique, subsequently validated by direct sequencing, was used for genotyping. Results: A significant difference in TT genotype was observed between two groups patient and control (OR=4.12, 95%CI=1.55-10.55, P=0.005). Also T allele frequencies of rs12255372 was different in the groups (0R=1.69, 95%CI=1.12-2.53, p=0.02). No allelic or genotypic association with T2D was detected for rs290487. Conclusion: Our finding suggest that TT genotypes rs12255372 confers an increased risk of developing T2D. The rs290487 is unlikely an influential variant with type 2 diabetes in this population.
Keywords: Type 2 Diabetes, TCF7L2, Polymorphisms, Arab
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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