جمعه 1 شهريور 1398
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   أوت 23, 2019
   
   
     
  تعداد اعضاء : 3354 نفر
  بازدیدهای امروز :501 بار
  تعداد کل بازدیدها : 491068 بار
   
Volume: 41
Year: 2019
Month: 7
Subject Others
Title The effect of anaerobic exercise with melatonin consumption on the expression of Bax and Bcl-2 markers in rat myocardium after ischemic-reperfusion
Authors Hamed Alizadeh Pahlavani; Hamid Rajabi; Mohammad Nabiuni; Pezhman Motamedi; Neda Khaledi;
Abstract Background: The present research aims to examine the effect of anaerobic exercise with melatonin consumption on the expression of Bax and Bcl-2 markers in rat myocardium after ischemic-reperfusion by isoprenaline. Methods: In the present experimental study, 28 male Wistar rats weighing approximately 200-250 g with two to three months old were divided into five groups: pilot (n=14), control (n=4), melatonin (n=4), anaerobic (n=4) and melatonin anaerobic (n=4). Pilot group were divided into two groups, isoperalin (n=7) and normal (n=7): isoperalin group injected isoprenaline with dose of 150 and 125 mg/kg BW with 24 hours in two consecutive days; and normal group has no injection. Then more fibros level was confirmed in isopernalin into normal groups used Masson-trichrom tanique. In the following Rats in melatonin group were gavaged every day for one month using a dose of 10 mg/kg BW. Meanwhile, rats in anaerobic group and melatonin anaerobic group were exposed training course with frequency of three times weekly for one month. But control group were injected only with isopernalin in the end of one month. Finally, rats were sacrificed after confirmation of infarct and expressions of bax and bcl2 gene were studied by real-time method. Results: Melatonin treatment and anaerobic training have negligible effect on Bax and Bcl-2 gene expression. In the other hand, anaerobic exercise with consuming melatonin can decrease and increase Bax and Bcl-2 gene expression respectively and show significant effect, compared to treatment with melatonin alone. Conclusion: The anaerobic exercise with consuming melatonin into consuming melatonin alone can reduce inactive induced-Infarction level.
Keyword: Apoptosis, Anaerobic Exercise, Melatonin, Reperfusion, Bax, Bcl2.
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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