يکشنبه 10 فروردين 1399
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   مارس 29, 2020
   
   
     
  تعداد اعضاء : 3812 نفر
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Volume: 42
Year: 2020
Month: 3
Subject Others
Title A comparative study of hsa-miR-15 gene expression changes in myocardial infarction patients with healthy individuals in Shahid Madani Hospital of Tabriz
Authors Eslam Shiri; Saeid Ghorbian;
Abstract Background: miRNA is one of those biomarkers that have different types. Hsa-miR-15 is one of the molecules, which expressed in the heart tissue. MiRNAs are small non-coding RNA that regulates complex cardiac signaling and transcription pathways in cardiac during different condition. The aim of this study was to compare hsa-miR-15 gene expression changes in myocardial infarction patients with healthy individuals. Methods: In this case-control study, which was included 88 patients with myocardial infarction and 19 healthy individuals who had been referred to the Shahid Madani hospital of Tabriz. After total RNA extraction and cDNA synthesis, the hsa-miR-15 gene expression changes were assessed using Real-time PCR method. For data analysis, we have used independent t-test. Results: The hsa-miR-15 gene expression changes increased in the patients with myocardial infarction compared to healthy individuals. The level of hsa-miR-15 gene expression was shown a statistically significant difference between groups (p >0/05). Conclusion: The hsa-miR-15gene expression increased in the patient with myocardial infarction and may be used as a biomarker in early diagnosis of myocardial infarction.
Keyword: Myocardial Infarction, miRNA, hsa-miR-15, Tabriz
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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