يکشنبه 10 فروردين 1399
به سایت مجله پزشکی دانشگاه علوم پزشکی و خدمات بهداشتی و درمانی تبریز خوش آمدید
   مارس 29, 2020
   
   
     
  تعداد اعضاء : 3812 نفر
  بازدیدهای امروز :445 بار
  تعداد کل بازدیدها : 659726 بار
   
Volume: 42
Year: 2020
Month: 3
Subject Others
Title Lack of association between the variant rs10735810 in the VDR gene and the pathogenicity of Multiple Sclerosis in patients of Khuzestan MS Society
Authors Hamid Galehdari; Masumeh Ranjbar; Parisa Mohammadi-Nejad; Tahere Seifi; Nastaran Majdi-Nasab;
Abstract Background: Multiple sclerosis (MS) seems to be a multifactorial disease in which the environment and genetics are involved. One of the factors associated with MS disease is the reduction in vitamin D levels and its specialized role in its pathogenicity. In Iran, Khuzestan province has a high relative incidence of the Multiple sclerosis (MS) after the provinces of Isfahan and Markazi, The polymorphism rs10735810 in the VDR gene with change in the initial codon is one of the factors associated with other known diseases, including osteoporosis and diabetes. Methods: In this study, the association of this variant in one hundred and fifty individuals with MS disease was compared with one hundred and fifty healthy individuals. PCR-sequencing was used to determine genotypes. Results: In the patient group, 16 cases had CC genotype, 59 had CT genotype and 75 had TT genotype, which did not show any significant difference in comparison with the control group (P>0.05). Also, there was no significant difference in the alleles distribution in the patient population compared to control (50% vs. 47.55% P=0.47). Additionally, no association was found between age and sex, and the ethnicity of patients (p> 0.05). Conclusion: The polymorphism rs10735810 in the VDR gene showed no association to the etiology of MS.
Keyword: Multiple sclerosis, Gene variants, Vitamin D, Khuzestan Province
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ISSN 1608-5671 (Print)  

ISSN 2008-160X (Online)  
 
     
     
 

ضريب تأثير (IF) مجله پزشکی دانشگاه علوم پزشکی تبریز  در  پايگاه  استنادي علوم جهان اسلام (ISC)  

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